ABSTRACT
Neurologic symptoms have been reported in over 30% of hospitalized patients with coronavirus disease 2019 (COVID-19), but the pathogenesis of these symptoms remains under investigation. Here, we place the neurologic complications of COVID-19 within the context of three historical viral pandemics that have been associated with neurologic diseases: (1) the 1918 influenza pandemic, subsequent spread of encephalitis lethargica, and lessons for the study of COVID-19-related neuroinflammation; (2) the controversial link between the 1976 influenza vaccination campaign and Guillain-Barré Syndrome and its implications for the post- and parainfectious complications of COVID-19 and COVID-19 vaccination; and (3) potential applications of scientific techniques developed in the wake of the human immunodeficiency virus pandemic to the study of postacute sequelae of COVID-19.
Subject(s)
COVID-19 , Guillain-Barre Syndrome , Influenza, Human , Nervous System Diseases , Humans , COVID-19/complications , COVID-19/epidemiology , Pandemics , Influenza, Human/complications , Influenza, Human/epidemiology , Influenza, Human/prevention & control , COVID-19 Vaccines , Nervous System Diseases/etiology , Nervous System Diseases/complications , Guillain-Barre Syndrome/etiology , Guillain-Barre Syndrome/complicationsABSTRACT
Global health electives in neurology residencies provide opportunities for high-income country trainees, but have limited benefits-and may create burdens-for lower-income country hosts. Current suspension of global health electives for U.S. neurology residents due to the COVID-19 pandemic provides an opportunity to reflect on ways to reimagine global health education during this period and beyond. The framework proposed in this article underscores the need for equitable, bidirectional international partnerships and highlights global health educational innovations developed during the pandemic.